Jian Xu

  • Sep 17, 2018

Date & Location: September 17, 2018, at 4p; Room 1200 Molecular Plant Sciences Building

Subject: Nannochloropsis as chassis for producing “designer oils” from carbon dioxide

Host: Christoph Benning

About the Speaker

University: Chinese Academy of Sciences

Abstract: Marine microalgae capture a significant portion of atmospheric carbon dioxide and store the fixed carbon as energy-dense macromolecules such as oil or starch. However, for industrial oleaginous microalgae, understanding and rational engineering of such intracellular carbon capture and storage machineries have just begun. Using Nannochloropsis oceanica as a model, we unveiled an intricate collaborative network of genes that underlies TAG synthesis, and showed that the fatty acid profiles on TAG can be rationally designed, for tailored benefits to nutrition and health. Along the process, we develop a series of targeted engineering tools to manipulate these networks. Moreover, we propose a concept called Ramanome to rapidly phenotype and screen individual microalgal cells based on their metabolic state at single-cell resolution, and then develop Raman-activated Cell Sorter (RACS) to establish the phenotype-genotype link at single-cell resolution. In the end, I will present my thoughts for collaboratively crafting Nannochloropsis oceanica into a chassis for scalable production of biofuels, biomaterials and nutrients from carbon dioxide.